β-Lactam Continuous Infusion · PK/PD
Impact of a Loading Dose
CONCENTRATION – TIME PROFILES · CONTINUOUS INFUSION ± LOADING DOSE
MIC
C target (4×MIC)
T < MIC ≈ 0.5 h
Loading
dose
0
2
4
6
8
10
12
Time (hours)
0
1
2
3
4
5
6
Concentration (× MIC)
With loading dose
Immediate target attainment
T > MIC: 100%
No loading dose
Gradual rise to steady state
T < MIC: ~0.5 h
MIC
Minimum inhibitory conc.