β-Lactam PK/PD
Infusion Strategy Comparison
CONCENTRATION – TIME PROFILES
— MIC
0
4
8
12
16
20
24
Time (hours)
0
2
4
6
8
10
Concentration (× MIC)
Intermittent
30-min infusion
T > MIC: ~30%
Extended
3–4 h infusion
T > MIC: ~70%
Continuous
24-h infusion
T > MIC: 100%
▸ Same Daily Dose
▸ ↑ T > MIC
▸ ↓ Peak Toxicity